Clues to curbing obesity found in neuronal 'sweet spot' («Science-News»)

Preventing weight gain, obesity, and ultimately diabetes could be as simple as keeping a nuclear receptor from being activated in a small part of the brain, according to a new study by Yale School of Medicine researchers.

Published in the Aug. 1 issue of The Journal of Clinical Investigation (JCI), the study showed that when the researchers blocked the effects of the nuclear receptor PPARgamma in a small number of brain cells in mice, the animals ate less and became resistant to a high-fat diet.

"These animals ate fat and sugar, and did not gain weight, while their control littermates did," said lead author Sabrina Diano, professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine. "We showed that the PPARgamma receptor in neurons that produce POMC could control responses to a high-fat diet without resulting in obesity."

POMC neurons are found in the hypothalamus and regulate food intake. They are the neurons that when activated make you feel full and curb appetite. PPARgamma regulates the activation of these neurons.

Diano and her team studied transgenic mice that were genetically engineered to delete the PPARgamma receptor from POMC neurons. They wanted to see if they could prevent the obesity associated with a high-fat, high-sugar diet.

"When we blocked PPARgamma in these hypothalamic cells, we found an increased level of free radical formation in POMC neurons, and they were more active," said Diano, who is also professor of comparative medicine and neurobiology at Yale and director of the Reproductive Neurosciences Group.

The findings also have key implications in diabetes. PPARgamma is a target of thiazolidinedione (TZD), a class of drugs used to treat type 2 diabetes. They lower blood-glucose levels, however, patients gain weight on these medications.

"Our study suggests that the increased weight gain in diabetic patients treated with TZD could be due to the effect of this drug in the brain, therefore, targeting peripheral PPARgamma to treat type 2 diabetes should be done by developing TZD compounds that can't penetrate the brain," said Diano. "We could keep the benefits of TZD without the side-effects of weight gain. Our next steps in this research are to test this theory in diabetes mouse models."

Other Yale authors on the study included Lihong Long, Chitoku Toda, Jin Kwon Jeong, and Tamas Horvath.

The study was funded by the National Institutes of Health (RO1DK097566)

Golden Eagle Tries To Snatch Up Baby Chillin In The Park

Parents watch your children at all time..

Promote parental responsibility by posting "You are Responsible For Your Child Safety" swimming pool sign. Keep children safe

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Top 5 Diet Pills for Fast Weight Loss

DietRatings.org, a subsidiary of Applied Nutritional Research, is a one-stop consumer resource designed to help you compare the latest diet products available to consumers and learn about diet products that deliver proven weight-loss results instead of empty promises. On a month-to-month basis, we provide in-depth analysis on our top-rated diet products, providing consumers with the most up-to-date and complete diet product ratings and recommendations. Our Proprietary 3-Stage Ratings System will help you find the market's best diet products that are not only clinically proven but also user recommended for fast, safe weight loss and fat reduction. Rating each product on weight loss power, speed of results, product safety,consumer reviews, and company reputation, we issue diet product recommendations consumers can use to help them make smart buying decisions. You can be assured that with every review, we cut through the marketing hype to help you find the most effective diet products at the most cost-effective prices.

Number: 1 Stores Across the U.S and U.K. Can't Keep the Popular Fat Buster in Stock...

Raspberry ketone supplements have become nearly impossible to find in stores after Dr. Mehmet Oz, mentioning no specific brand, hailed it as "The No. 1 Miracle in a Bottle to Burn Fat" on his popular daytime television show.

Study: Subjects Lost 8.9 lbs & 2 Inches in Just 28 Days

Try the Breakthrough Weight-Loss Product Featured on The Dr. Oz Show...
African Mango Extract is currently one the most popular weight-loss product in America after Oprah's favorite doctor, Dr. Oz, featured it on his nationally syndicated television show on September 13, 2010.
Dr. Oz, mentioning no specific brand, called African Mango a "breakthrough supplement" and a "miracle in your medicine cabinet" that can help you quickly lose 10 pounds. Click here to read more about what Dr. Oz says about African Mango.
The active ingredient in Pure African Mango (a rare mango native to the rainforests of Cameroon, West Africa) is a unique extract called Irvingia Gabonensis.
According to a new study published in the medical journal Lipids in Health and Disease, this extract caused an average weight loss of 8.9 pounds in 28 days.
What's more, subjects supplementing with this extract experienced significant decreases in bad LDL cholesterol, triglycerides, and glucose levels. No negative side effects were reported in the clinical research.
In our years of reviewing clinical research, no other diet pill has facilitated such a large weight loss within 28 days.
After interviewing 250 Pure African Mango customers, as well as reviewing the clinical research studies, this product is our #2  recommendation for 2012.

Bonus: Last day for FREE Express Shipping. At checkout, use Coupon Code: mango

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Click Here to Visit the Official Pure African Mango Website

Number: 2

Indeed, health food stores across the U.S. and U.K. have been barraged from customers seekingraspberry ketones — an extract from raspberries, which new research shows possesses extremely potent fat-fighting properties.

Raspberry ketones are the compounds within raspberries that give the fruit its characteristic aroma. More important to dieters, however, is new research showing these compounds can also melt away the pounds.
According to Lisa Lynn, a weight-loss expert and fitness contributor to The Dr. Oz Show, many of her clients have been supplementing with raspberry ketones and experiencing stunning fat-loss results in as few as five days
Lynn described the compounds as "very healthy" with "no side effects" and says the pills enable the body to "burn fat easier" by stimulating the production of adiponectin, a hormone found in fatty tissue that improves our ability to metabolize fat.
Studies show that thin people have higher levels of adiponectin than overweight individuals. What's more, researchers agree that the hormone improves insulin sensitivity and helps regulate weight.

How You Can Put Raspberry Ketone to the Test...

Good luck trying to find raspberry ketones in stores. Many U.S. health-food retailers like GNC have been on backorder since The Dr. Oz Show first aired in February.

Even stores in the United Kingdom are completely sold out of the fat buster, according to a new report in Britain's Daily Mail online.

A few online retailers, who stocked up on raspberry ketone before The Dr. Oz Show aired, still have supplies available to customers.

Consumer Tip: Avoid most bargain-basement "Raspberry Ketone" products advertised on Google, as well as other online search engines — more often than not, these are cheap imitation knock-offs imported from China. These low-quality rip-offs will not deliver the same results of pure American-manufactured, pharmaceutical-grade Raspberry Ketone products.

According to consumer and Better Business ratings, the Raspberry Ketone Fat-Loss Formula from Applied Nutritional Research is considered one of the most effective and trustworthy, with laboratory tests certifying the product's potency and quality.

Each serving of Raspberry Ketone Fat-Loss Formula contains 300 mg of raspberry ketones — one of the highest concentrations currently available (most products offer just 100 mg per serving).
The website offers a 100% risk-free trial of the product, with each serving working out to be just 62 cents — less than what you'd spend on a small sugary softdrink at McDonald's.
What's more, each an every order of Raspberry Ketone Fat-Loss Formula is a one-time-only transaction. In other words, there are absolutely no reoccurring charges or hidden offers.

Bonus:Last day for FREE Express Shipping. At checkout, use Coupon Code: ketone

Note: Coupon Code Expires Today, August 30, 2012
Number 3

Clinically Proven to Reduce 1 Inch of Belly Fat Every 28 Days

Phosphacore Extra-Strength Abdominal-Fat Oxidizer is also soaring up the charts for its clinically proven belly fat-fighting benefits.

The active ingredient in Phosphacore is an extract from the plant species Carthamus tinctorius, a unique plant native to North-Central Africa. According to new 28-day study from scientists at the Department of Public Health at Sweden's Uppsala University, subjects taking this nutrient lost an average 600% more abdominal fat than people taking a placebo -- this amounted to an average abdominal fat loss of nearly 1 inch every 28 days.

In another new study published in The American Journal of Clinical Nutrition, scientists from the University of Wisconsin found that people taking this nutrient lost on average 900% more total bodyfat per week relative to subjects who consumed a placebo. This included excess fat from the abdominal region, legs, buttocks, and arms. 

After interviewing 250 Phosphacore customers, as well as reviewing the clinical research studies, this product is our #2 recommendation for 2012 -- and a top recommendation for people wanting to lose belly fat specifically.

Number 4

Fox News: Maqui Berry is 2012's 'Super Fruit' of the Year

After FOX News Channel medical contributor Dr. Manny Alvarez highlighted the remarkable healing benefits of Maqui Berry — 12.6 times more powerful than Acai Berry — sales of Maqui Berry have skyrocketed, making it now one of the most popular weight-loss products in America today.

Internet searches reveal countless blog postings and Facebook messages, singing the praises of this new weight-loss wonder fruit.

Clinical research shows Maqui Berry is known to have highest levels of a powerful fat-burning nutrient called anthocyanins of any food on earth. In fact, it contains over 10 times more anthocyanins than any other food source. 

Studies show anthocyanins have remarkable weight loss and fat-burning properties. A new study from Japan shows anthocyanins have "significant potency" against fat cells and strong "anti-obesity" benefits.Click here to read the study results.  

Experts Offer High Praise for Maqui's Slimming Promise 

According to Chris Kilham, a professor of ethnobotany at the University of Massachusetts Amherst, Maqui berry may aid fat loss by helping support optimal blood glucose levels. 

"Interestingly, intake of maqui berries or their juice causes a significant increase of insulin in the body, says Kilham. "In fact, Maqui appears to do this better than any other known plant. What does this mean? Consuming maqui berries or their juice with or after meals can help to suppress blood glucose, thereby evening out energy and preventing the formation of new fat cells. As a result, maqui may prove to be a beneficial aid in weight control." 

Number 5:

Rare, Delicious, Fat-Burning Coffee from Biblical Red Sea

Moyojava Organic Ethiopian Coffee, while not technically a diet pill, makes our ratings for its potent fat-fighting benefits.

Researchers say the secret to this coffee's mysterious slimming properties is found in the coffee beans used to make this delicious brew. The bean is found only in the secluded mineral-rich Red Mountains of Ethiopia. The rich red soils in which this rare bean is grown is the same soils which give the Red Sea its mysterious "ruddy complexion."

This coffee has been consumed for centuries among the village people of Africa's ancient Red Mountains and Great Rift Valley along the Biblical Red Sea. The coffee is uniquely rich in phytonutrients, antioxidants and one curious compound called cholorgenic acid.

According to a new study published in the scientific journal Complementary and Alternative Medicine, this nutrient caused a 35% reduction in bodyfat.

Moyojava Organic Ethiopian Coffee is a hundreds-year-old beverage just now being introduced to the mainstream, and it's our #4 recommendation for 2012 -- a perfect choice for coffee and tea drinkers. We've received many letters from customers who've achieved even greater bodyfat loss by using this coffee in conjunction with Phosphacore and/or Pure African Mango. 

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Source: http://www.dietratings.org

Cynthia to be buried Sept 7 – Family

Mrs Joy Osokogu , who announced the date to journalists in Jos on Monday, advised youths to be very cautious of making friends with people that they did not know.

“The youths should be very careful, especially when they are making friends in the social media. Like we have seen in the case of my daughter, such friends may have ulterior motives.

Osokogu described her deceased daughter as “very industrious, hard working and a respectful child.

“She was my daughter, my friend and my sister. Her memory will never be forgotten because she touched so many lives positively in her short stay on earth,” she said.

Osokogu said Cynthia’s killers had demanded N20 million ransom from the family.

“The killers of my daughter demanded a ransom of N20 million from my son, Flt- Lt. Kenneth Osokogu,” she said.

Osokogu said the killers sent her son, who is in Makurdi, a text message demanding that he paid N20million into an account which did not exist.

“The killers were not picking our calls; they only communicated to us via text messages.

“When my son got their SMS, he later replied them that the account number was fake and didn’t exist.

“He sent another message in which he said that if it was a case of kidnapping, he would like to speak with his sister before making any payment but the killers did not respond,” Osokogu said.

She said, however, that when she spoke with the suspected killers, they did not ask her for any money.

Osokogu said she spoke last with Cynthia on July 22, when she called to say that she was travelling to Lagos to get her goods.

“But the next day, I didn’t hear from her. When I tried to reach her, all her phones were switched off.

“After one week, the phones started ringing but no one was picking.

“Few days later, people I believe to be the killers, called and said that my daughter was in one Symbol Hospital in Lagos.

“I called the police I had earlier reported the case to, to go and verify if she was in the hospital, they said there was no hospital like that.

“After a while, I called the number and told them I wanted to speak with her but they said that it was not possible.

“When I asked why, they said she would come back but that I wouldn’t speak with her.

“When I called the number again, they said they had killed her and that was when we declared Cynthia missing,’’ Osokogu said..

The police in Lagos last week announced the arrest of some persons in connection with the murder of Cynthia. (NAN)

Penis Snake Discovered In Brazil

A group of engineers building a dam in the Amazon recently discovered an Atretochoana eiseltiis, better known as a caecilian, which some people might know as a limbless amphibian, but, let’s be honest, the creature pictured above is a penis snake

that the strange creature was discovered while the Madeira River was being drained as part of a damn building project in Brazil’s Madeira River. Biologist Julian Tupan said that six penis snakes were found at the bottom of the river.

Tupan said:

“Of the six we collected, one died, three were released back into the wild and another two were kept for studies. Despite looking like snakes, they aren’t reptiles and are more closely related to salamanders and frogs. We think the animal breathes through its skin, and probably feeds on small fish and worms, but there is still nothing proven.The Amazon is a box of surprises when it comes to reptiles and amphibians. There are still much more to be discovered.” 

The Digital Journal notes that the discovery was made last November but it was only announced this week after biologist deemed that it was a new species.

Informally, the new Amazon River dweller is being called a “floppy snake,” but media outlets are having a little fun coming up with names like penis snake and man-aconda.

 Anybody else have a good name for the Atretochoana eiseltiis?

Usher’s Young Stepson Reportedly Hit by A Jet Ski, Hospitalized in Critical Condition

11-year-old Kyle Glover, the son of Usher’s ex-wife Tameka Foster, is reportedly in critical condition after being hit by a jet ski.

Eye Witness, is reporting that Glover was inner tubing on Lake Lanier in Georgia when a jet skier crashed into him.

According to the site, Usher’s stepson was unresponsive and transported to an Atlanta hospital.

Glover’s status and injuries have not been confirmed.

Usher and Foster are in the midst of a bitter divorce battle, but the singer is said to have chartered a flight for Foster to race back to Atlanta to be with Glover.

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Justin Bieber Feat - Ludacris - All Around The World

Pop Star In Line 

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